نوع مقاله : مقاله پژوهشی
1 گروه زیست شناسی، دانشکده علوم پایه، دانشگاه حکیم سبزواری، سبزوار، ایران
2 عضو هیات علمی گروه زیست شناسی، دانشکده علوم پایه، دانشگاه حکیم سبزواری، سبزوار،ایران
3 گروه ژنتیک پزشکی و پزشکی مولکولی
عنوان مقاله [English]
Introduction: Skin melanoma is one of the most invasive types of skin cancer. It accounts for about 75% of all skin cancer deaths and has not yet been definitively treated. As a result, early diagnosis and prevention of the disease is important. Much research has been done to find ways to treat and cure cancer. One of the newest methods in this field is the use of nanotechnology to detect and inhibit cancer cells. In this study, the effect of using Nano microbubbles of Air, Oxygen and Ozone on A375 melanoma cancer cell line was evaluated.
Materials and Methods: A375 cell line treated with different concentrations of Nano microbubbles of Air, Oxygen and Ozone and were evaluated by MTT method. In order to measure cell viability, MTT plate was added to each well and then the plate was incubated.
Results: According to the results of this study, a decrease in the viability of A375 cancer cells with an increase in the concentration of Oxygen and Ozone Nano microbubbles after 24 hours indicates apoptosis and has a significant inhibition of the growth of these cells.
Conclusion: The results of this study indicate that Nano microbubbles of Oxygen and Ozone in high concentrations cause cell death of A375 cell line. The results of this study will help investigate the role of Nano microbubbles of Air, Oxygen and Ozone in the treatment of melanoma cancer.