نوع مقاله : گزارش مورد
نویسندگان
1 دپارتمان بیماریهای داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
2 مرکز تحقیقات بیماریهای ریوی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
3 مرکز توسعه تحقیقات ،بیمارستان قائم، دانشگاه علوم پزشکی مشهد، مشهد، ایران
4 دپارتمان بیماریهای داخلی،دانشکده پزشکی،دانشگاه علوم پزشکی مشهد، مشهد ، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Neuroleptic malignant syndrome (NMS) is a neurologic emergency condition that may arise as a result of the administration of potent psychotropic agents but it is not only antipsychotics alone that should be blamed for being behind the occurrence of this syndrome . This syndrome is characterized by fever and rigidity. Further symptoms include impaired consciousness, autonomic dysfunction, increased creatine kinase (CK), and leukocytosis. We report a case of a middle age woman with a past medical history of depression presented to the emergency room with alteration of mental status , neuromuscular hyper excitability, pyrexia, muscle rigidity and urinary incontinence following ingestion of clomipramine, a drug not noted for dopamine blockade. A firm diagnosis of NMS was made . After discontinue medication, therapy with Bromocriptine and Lorazepam was started. Within a few days, the patient improved significantly and CPK level returned to normal after 5 days.It is necessary to mention that the use of drugs other than antipsychotic agents can lead to NMS. Likely, the number of agents that can precipitate this syndrom will most probably increase by years.
کلیدواژهها [English]