نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه فیزیولوژی ورزش، دانشگاه آزاد اسلامی واحد تهران جنوب، تهران، ایران
2 استادیار، گروه فیزیولوژی ورزشی، دانشگاه آزاد اسلامی، واحد تهران جنوب، تهران، ایران.
3 عضو هیات علمی دانشگاه آزاد واحد ساوه
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Hepatic glucose release is one of the most important causes of hyperglycemia in type 2 diabetics. The present study was conducted with the aim of determining the effect of intense interval training on RBP4 gene expression of in liver hepatocytes, as well as blood glucose and insulin levels in type 2 diabetic (T2D) rats.
Methods: For this purpose T2D induced by intraperitoneal nicotinamide and STZ in 14 male Wistar rats (10 week old, 220 ± 10 g), then they were divided into control (n=7) and interval (n=7) groups. Rats in the interval group performed a 4-week interval training program (5 sessions per week) in the form of running on a treadmill. The control group did not participate in the exercise program. 48 hours after the last training session, RBP4 gene expression in hepatocytes as well as serum insulin and fasting glucose were compared between groups by independent t-test.
Results: Interval training led to a significant decrease in fasting glucose (p = 0.001) and RBP4 gene expression in liver cells (p = 0.031) compared to the control group. Also, serum insulin increased significantly in response to interval training compared to the control group (p = 0.001).
Conclusion: Based on these findings, the improvement of fasting glucose in response to interval training may be attributed to the reduction of RBP4 in liver hepatocytes. However, knowing the mechanisms responsible for the effect of exercise on glycemic profile requires more studies.
کلیدواژهها [English]