بررسی مقایسه تاثیر دو داروی کتورولاک و پتدین در بی‌دردی پس از عمل جراحی ارتوپدی اندام تحتانی به روش بی‌حسی اسپاینال

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه ارتوپدی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

2 گروه بیهوشی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

3 کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

چکیده

مقدمه: درد بعد از اعمال جراحی یک تجربه ی ناخوشایند است که به دنبال محرک های مختلف بوجود می آید و انسان نسبت به آن واکنش نشان می دهد. این فرایند باعث می‌شود اختلالات فیزیولوژیک در تمام سیستم های بدن بوجود آید. لذا هدف از انجام
روش کار: در این مطالعه کارآزمایی بالینی تصادفی شده سه سویه کور، 59 بیمار با کلاس بیهوشی 1و 2 تحت عمل جراحی ارتوپدی اندام تحتانی با بی‌حسی اسپاینال قرار گرفتند. بیماران به 4 گروه، پتدین، کتورولاک، دارونما و ترکیب کتورولاک و پتدین تقسیم شدند. جهت اندازه گیری درد بیماران از معیار VAS استفاده شد.
نتایج: بین گروه‌های کتورولاک، پتدین، دارونما و کتورولاک+پتدین از لحاظ فشارخون سیستول و دیاستول و ضربان قلب تفاوت آماری معنی‌داری مشاهده نشد. درصد اشباع اکسیژن در قبل و بعد از اسپاینال، 15 دقیقه بعد از عمل معنی‌دار بود (05/0p<). ولی در زمان‌های دیگر تفاوت معنی‌دار وجود نداشت (05/0p>). از لحاظ درد در ریکاوری، در 6 و 12 ساعت بعد از عمل، تفاوت معنی‌دار وجود داشت (05/0p<). ولی در زمان‌های دیگر، تفاوت معنی‌دار نبود. در 6 ساعت بعد از عمل، درد شدید در بیماران گروه‌های پتدین و دارونما مشاهده شد و در بیماران گروه‌های کتورولاک+پتدین و کتورولاک وجود نداشت؛ اما در 12 ساعت بعد از عمل، درد شدید در بیماران گروه پتدین بیشتر از گروه‌های دیگر شایع بود و در بیماران گروه کتورولاک+پتدین وجود نداشت.
نتیجه‌گیری: نتایج این مطالعه بیانگر آن بود که کتورولاک و ترکیب کتورولاک+پتدین باعث کاهش بی‌دردی در بیماران تحت عمل جراحی ارتوپدی اندام تحتانی می‌شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Comparative study of the infusion of ketorolac and Pethidine in reducing postoperative pain in patients undergoing orthopedic surgery of lower limbs under spinal anesthesia

نویسندگان [English]

  • Shahram Shafa 1
  • Hasan Zabetian 2
  • Ameneh Ranjbar 3
  • Navid Kalani 2
1 Department of Orthopedics, Jahrom University of Medical Sciences, Jahrom, Iran.
2 Department of Anesthesiology, Jahrom University of medical sciences, Jahrom, Iran.
3 Student research committee, Jahrom University of medical sciences, Jahrom, Iran
چکیده [English]

Introduction: Pain after surgery is an unpleasant experience that occurs following various stimuli and people react to it. This process causes physiological disorders in all systems of the body.
Method: In this three-way, randomized clinical trial, 59 patients with anesthesia classes 1 and 2 underwent lower limb orthopedic surgery with spinal anesthesia. Patients were divided into 4 groups: pethidine, ketorolac, placebo and a combination of ketorolac and pethidine. VAS criterion was used to measure patients' pain.
Results: There was no statistically significant difference between ketorolac, pethidine, placebo and ketorolac + pethidine groups in terms of systolic and diastolic blood pressure and heart rate. Oxygen saturation percentage before and after spinal was significant 15 minutes after surgery (p <0.05). But at other times there was no significant difference (p> 0.05). There was a significant difference in terms of pain in recovery at 6 and 12 hours after surgery (p <0.05). But at other times, the difference was not significant. At 6 hours postoperatively, severe pain was observed in patients in the pethidine and placebo groups and in patients in the ketorolac + pethidine and ketorolac groups; However, at 12 hours postoperatively, severe pain was more common in patients in the pethidine group than in the other groups and was not present in patients in the ketorolac + pethidine group.
Conclusion: The results of this study showed that ketorolac and the combination of ketorolac + pethidine reduce analgesia in patients undergoing orthopedic lower limb surgery.

کلیدواژه‌ها [English]

  • Ketorolac
  • Pethidine
  • Orthopedics
  • Spinal Anesthesia
  • Analgesia

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مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
دوره 67، شماره 2
خرداد-تیر1403
خرداد و تیر 1403
صفحه 505-521

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