نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار ارتوپدی ، دانشگاه علوم پزشکی مشهد، مشهد، ایران
2 دانشیار رادیولوژی ، دانشگاه علوم پزشکی مشهد، مشهد، ایران
3 استادیار طب فیزیکی و توانبخشی ، دانشگاه علوم پزشکی مشهد، مشهد، ایران
4 متخصص ارتوپدی، مشهد، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Introduction
Thalassemia major is a hereditary anemia that becomes blood transfusion dependent. Iron overload consequence leads to multiple organ dysfunction and endocrinopathy. So deferoxamine (desferal) is used for chelation therapy. The aim of this study was to evaluate the growth rate of these patients and its correlation with endocrine complications and determine the role of secondary iron overload in these situations.
Materials and Methods
This cross-sectional study was performed for a year (2010) on 280 patients (aged 3.5- 56 years) who received blood transfusion and chelation therapy at Amirkola Thalassemia Center. After basic evaluations, determination of height standard deviation, they were divided by serum ferritin level into two groups (good and poorly controlled). They were evaluated for hypothyroidism, diabetes mellitus, hypoparathyroidism and hypogonadism. Next, data were analyzed. A p Result
From 280 patients with mean age of 19.6 ± 8.5 years, 161 (57.5%) cases were female, short stature (Conclusion
According to higher prevalence of hypoparathyroidism, hypogonadism and diabetes mellitus in short statured thalassemic patients, screening should be done for such disorders with more sensitivity in these patients.
کلیدواژهها [English]