نوع مقاله : مقاله پژوهشی
1 دانشیار گروه داخلی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
2 کارشناس ارشد هماتولوژی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
3 دانشیار گروه بیوشیمی و تغذیه، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد،مشهد، ایران
4 دانشیار گروه پزشکی اجتماعی و بهداشت، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
5 عضو هیئت علمی دانشکده پیراپزشکی، دانشگاه علوم پزشکی زاهدان
عنوان مقاله [English]
Prevalence of folate and cobalamin deficiency in elderly is high. Determining a cut off point forlow and marginal levels of folate and cobalamin deficiency before development of anemia or neurocognitive presentations in elderly is essential.
Materials and Methods
In this cross-sectional study 280 persons above 65 years old in the twelve regions of Mashhad city were admitted to Emam Reza (pbuh) hospital. They were physically examined by a general practitioner. Other data were obtained by questionnaire. Serum cobalamin and folate level were analyzed by RIA method. 76 persons, who had cobalamin of 120-450 pg/ml and folate of 1.5-7 ng/ml without any interfering factor for homocystein (Hcy) measurement (creatinin>1.5g/dl, cigarette smoking and consuming certain kind of drugs) were analyzed for serum homocystein by Elisa method. All collected data was statistically analyzed by SPSS software.
48.7% of elderly had hyperhomocysteinemia. Hcy was inversely correlated with cobalamin (p=0.001) and folate below cut off point (p=0.044). For Hcy>15 mol/lµ, cut off points for cobalamin and folate deficiency were
According to definition of cut off point, Prevalence of cobalamin & folate deficiency especially in marginal levels was higher than which is recorded. It is recommended that before development of signs and symptoms and other complications of hyperhomocysteinemia, all elderly patients undergoes screening for cobalamin and folate deficiency in appropriate intervals.